A little more on C and scurvy.
Although for convenience I refer to vitamin C and ascorbic acid (AA), I admit that no one in Nelson's day would have used or thought in these terms, which date from the first third of the 20th century.
Primates, including humans, cannot synthesize their own vitamin C as most other animals can, and need an external dietary source. We are generally told that the human body cannot appreciably store vitamin C because no one wants to imply that it's all right for people to forgo daily intake. However, limited amounts of ascorbic acid are stored in the pituitary gland, adrenal glands, eye lens, liver, pancreas, spleen, kidney, heart, brain and other organs and tissues.
"The estimated total amount of ascorbic acid in the human body tissues is on average 1500mg (maximum 5g) when completely saturated. Any excess of vitamin C is rapidly excreted. About 4% of this pool is lost daily...after intermission of vitamin C supply. The biological half-time of the pool is therefore approximately 8 - 40 days...The first symptoms of scurvy occur upon reaching a total body pool of 300 - 400mg." (Elmadfa and Koenig, Subcellular Biochemistry, Volume 25, 1996, pp. 140-141.)
Thus the time to critical depletion and the onset of scurvy would depend on existing body stores as well as other factors that would vary from person to person, factors that might impair AA absorption and/or accelerate loss. These would include current overall health status, age, weight, gender, tobacco use (including chaw), alcohol use, environment, physical activity and psychological stress levels, and prior AA depletion-repletion experiences. Such variables might account for the surprising half-life spread indicated above. On average it might be more like 16 - 20 days.
The human body needs a minimum of 6.5mg - 10mg of vitamin C daily to prevent scurvy, assuming the body pool is depleted. This will not create new reserves. Even at saturation regular intake is critical. Routine consumption of smaller amounts of ascorbic acid is more beneficial than intermittent, inconsistent intake of higher doses.
Recovery from scurvy upon treatment can be comparatively rapid. If the sufferer were to get about 250mg four times a day he might be in reasonably good shape after a week, again depending on a number of things. If the individual had been through more than one cycle of critical depletion and then repletion, particularly if somewhat close together, his recovery time would be longer after each episode.
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Surgeon William Beatty wrote of Nelson: "And it is a fact, that early in life, when he first went to sea, he left off the use of salt, which he believed to be the sole cause of scurvy, and never took it afterwards with his food." (The Authentic Narrative of the Death of Lord Nelson.) Later in life, did Nelson still believe that salt caused scurvy? Was he blaming the food preservative itself rather than the fact of preservation?
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